Population
Isolated reactivatable stress fibers from cultured cells
Comparison
Rho-kinase vs Myosin light chain kinase (MLCK)
Design
Preclinical
Authors
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No immediate clinical implications for vascular tone; leaves open Rho-kinase targeting in cardiovascular research models.
This study demonstrates that actomyosin-based nonmuscle contractility is regulated by both Ca2+-dependent MLCK for rapid contraction and Rho-kinase for sustained contraction.
Katoh et al. (2001) studied this question.
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