Why the study?
Does matrix metalloproteinase inhibition prevent atherosclerotic plaque disruption?
Design
Review
Authors
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MMP inhibition should not yet change practice; leaves open clinical efficacy for plaque stabilization.
Does matrix metalloproteinase inhibition prevent atherosclerotic plaque disruption?
Matrix metalloproteinases play a key role in atherosclerotic plaque disruption and represent a potential therapeutic target for preventing ischemic cardiac events and stroke.
Loftus et al. (2002) studied this question.
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