In two widely separated hospitals a double-blind study of 171 hip operations was done, one group of patients receiving prophylactic cloxacillin, the other receiving a placebo. The first group had no postoperative infections, while the second had twelve (in eighty-eight patients). All of the patients had major surgery to the hip, and ten of the twelve infections were staphylococcal.
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Ericson et al. (1973) studied this question.