September 1, 1990Genes & DevelopmentOpen Access

Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

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Population

In vitro translation models using encephalomyocarditis virus (EMCV) cDNAs

Design

Preclinical

Authors

SJSung Key JangPohang University of Science and Technology EWEckard WimmerCalifornia Institute of Technology

Discussion

Member takes

Implication

No immediate clinical relevance; leaves open IRES targeting in human cardiovirus models.

Structured PICO

Population

In vitro translation models using encephalomyocarditis virus (EMCV) cDNAs

Intervention

Serial deletions and site-directed mutagenesis of the EMCV 5' nontranslated region (NTR)

Outcome

Translation efficiency and internal ribosomal entry site (IRES) functionsurrogate

This basic science study identifies key structural elements and a cellular protein required for cap-independent translation of EMCV RNA via an internal ribosomal entry site.

Cite This Study

Jang et al. (1990) studied this question.

synapsesocial.com/papers/6a0384d3edb78692da85fbdc https://doi.org/10.1101/gad.4.9.1560

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Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider