April 1, 1990Circulation
Determinants of survival and left ventricular performance after mitral valve replacement. Department of Veterans Affairs Cooperative Study on Valvular Heart Disease.
Why the study?
How do postoperative left ventricular size and systolic function relate to survival and clinical status in patients undergoing isolated mitral valve replacement?
Population
104 patients undergoing isolated mitral valve replacement
Comparison
Mitral valve replacement vs Preoperative baseline
Design
Cohort
Follow-up
6 months for hemodynamic evaluation; survival follow-up…
Authors
Discussion
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Member takes
Implication
May identify higher-risk patients after mitral valve replacement; leaves open whether targeting postoperative LV parameters improves outcomes.
Structured PICO
How do postoperative left ventricular size and systolic function relate to survival and clinical status in patients undergoing isolated mitral valve replacement?
P
Population
104 patients (48 with mitral regurgitation [MR], 33 with mitral stenosis [MS], and 23 with mixed MS/MR) undergoing isolated mitral valve replacement
I
Intervention
Mitral valve replacement
C
Comparator
Preoperative baseline (before and after surgery comparison)
O
Outcome
Survival and clinical status (New York Heart Association class) in relation to postoperative left ventricular size and systolic functionhard clinical
Postoperative left ventricular dilation and reduced ejection fraction are strong predictors of mortality and poor clinical status following isolated mitral valve replacement.
Cite This Study
Crawford et al. (1990) studied this question.