Torque teno virus viral load predicts SARS‐CoV‐2 vaccine response in kidney transplant recipients

This is the authors' abstract. We don't add key points for this paper.

copies (cp)/mL was independently associated with nonresponse to two doses (odds ratio (OR) = 6.17, 95% confidence interval (CI95) = 2.42-15.78) as well as to three doses (OR = 3.62, 95% CI95 = 1.55-8.49). In nonresponders to the second dose, high TTV VL in prevaccine samples or measured before the third dose were equally predictive of lower seroconversion rates and antibody titers. High TTV VL before and during SARS-CoV-2 vaccination schedules are predictive of poor vaccine response in KTR. This biomarker should be further evaluated regarding other vaccine responses.

High TTV VL may identify kidney transplant recipients at risk of vaccine nonresponse; leaves open prospective validation before clinical use.