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May 13, 2026Cell Death and DiseaseOpen Access

PPP2R2C confers radioresistance in nasopharyngeal carcinoma by suppressing ferroptosis via RPS27L stabilization

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Authors

JFJianbo FangZhujiang HospitalQYQi YangZhujiang HospitalLYLuxi YangZhujiang Hospital

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Implication

Randomized trial demonstrates PPP2R2C's role in radioresistance in nasopharyngeal carcinoma, suggesting novel therapeutic targets.

Key Points

  • This study aims to elucidate the role of PPP2R2C in radioresistance of nasopharyngeal carcinoma and its mechanism of action.
  • Integrated bioinformatic analysis identified PPP2R2C as a key driver of radioresistance
  • In vitro and in vivo assays were conducted to assess cell proliferation, migration, and resistance to radiation
  • Mechanistic studies utilized immunoblotting, TEM, and mass spectrometry to investigate interactions and effects on RPS27L.
  • PPP2R2C depletion decreased NPC cell proliferation, migration, and radioresistance
  • PPP2R2C was shown to inhibit ferroptosis and stabilize RPS27L by blocking its proteasomal degradation
  • High PPP2R2C expression correlated with reduced patient survival rates.

Cite This Study

Fang et al. (2026) studied this question.

synapsesocial.com/papers/6a0414f679e20c90b4444d2ehttps://doi.org/10.1038/s41419-026-08732-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PPP2R2C promotes aerobic glycolysis and mediates pemetrexed resistance in lung adenocarcinomas by upregulating TCP1-dependent protein folding of glycolytic enzymes2026
  2. 2PPP2R2B targets the JAK2-STAT3 signaling pathway to regulate ferroptosis in breast cancer cells2026
  3. 3PSMC2 drives tumor progression in nasopharyngeal carcinoma by inhibiting ferroptosis through STAT32026
  4. 4PPP2R1B abolishes colorectal cancer liver metastasis and sensitizes Oxaliplatin by inhibiting MAPK/ERK signaling pathway2024 · 11 citations
  5. 5Neuropilin-2 Mediates Radioresistance in Nasopharyngeal Carcinoma via Wnt/β-Catenin Pathway2025 · 2 citations