Key result
Oxidative stress drives anthracycline-induced cardiotoxicity via DNA damage, senescence, and cell death.
Population
Paediatric and adult cancer survivors exposed to anthracyclines
Design
Review
Authors
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Should not yet alter anthracycline cardiotoxicity management; leaves open trials targeting oxidative stress pathways.
This review summarizes the oxidative stress-triggered cellular events, including DNA damage, senescence, and cell death, that contribute to anthracycline-induced cardiotoxicity.
Cappetta et al. (2017) conducted a review in Anthracycline cardiotoxicity. Anthracyclines (Doxorubicin) was evaluated. This review highlights oxidative stress-triggered cellular events, including DNA damage, senescence, and cell death, as central mechanisms driving anthracycline-induced cardiovascular toxicity.
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