Key result
LV global constructive work moderately correlates with invasive stroke work index in advanced HF.
Why the study?
Left ventricular myocardial work is a promising tool in heart failure, but its relationship with hemodynamic data from right heart catheterization has not been assessed in advanced heart failure.
Does non-invasive left ventricular myocardial work correlate with invasively measured stroke work index in patients with advanced heart failure?
Observational (n=44)
No
Does non-invasive left ventricular myocardial work correlate with invasively measured stroke work index in patients with advanced heart failure?
Effect estimate: r = 0.506
p-value: p=0.001
Non-invasive left ventricular myocardial work indices, particularly global constructive work, correlate significantly with invasively measured stroke work index in patients with advanced heart failure, offering a potential tool for comprehensive myocardial evaluation.
May support non-invasive myocardial assessment in advanced HF; hypothesis-generating pending prospective validation.
Objectives: This study aimed to explore the correlation between left ventricular (LV) myocardial work (MW) indices and invasively-derived LV stroke work index (SWI) in a cohort of patients with advanced heart failure (AHF) considered for heart transplantation. Background: Left ventricular MW has emerged as a promising tool for diagnostic and prognostic purposes in heart failure (HF) but its relationship with hemodynamic data derived from right heart catheterization (RHC) has not been assessed in patients with advanced heart failure yet. Materials and methods: Consecutive patients with AHF considered for heart transplantation from 2016 to 2021 performing RHC and echocardiography as part of the workup were included. Conventional LV functional parameters and LV MW indices, including LV global work index (GWI), LV global constructive work (GCW), LV global wasted work (GWW), LV global work efficiency (GWE), and other were calculated and compared with invasively-measured LV SWI. Results: = 0.002). Conclusion: Among LV MW indices, LV GCW correlated better with invasively-derived SWI, potentially representing a powerful tool for a more comprehensive evaluation of myocardial function.
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Landra et al. (2022) conducted an observational in Advanced heart failure (n=44). Echocardiographic left ventricular myocardial work indices vs. Invasive right heart catheterization was evaluated on Correlation between left ventricular global constructive work (GCW) and invasively-derived stroke work index (SWI) (r = 0.506, p=0.001). Left ventricular global constructive work significantly correlated with invasively-derived stroke work index (r = 0.506, p = 0.001) in patients with advanced heart failure.
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