Key result
Analysis of mouse hearts during perinatal development showed upregulation of transcripts like Kir2.1, Kir3.1, Nav1.5, and Cav1.2 after birth, while KCa2.3 and minK were downregulated.
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Hypothesis-generating for perinatal arrhythmia mechanisms; leaves open human validation and clinical translation.
Harrell et al. (2006) studied Normal heart development. Analysis of mouse hearts during perinatal development showed upregulation of transcripts like Kir2.1, Kir3.1, Nav1.5, and Cav1.2 after birth, while KCa2.3 and minK were downregulated.
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