Exercise capacity for survivors of cardiac transplantation or sustained medical therapy for stable heart failure.
Why the study?
Does cardiac transplantation improve exercise capacity compared to sustained medical therapy in survivors with severe heart failure?
Population
42 survivors of severe heart failure who underwent exercise testing after more than 6 months of follow-up…
Comparison
Cardiac transplantation vs Sustained medical therapy tailored to…
Design
Cohort
Follow-up
14 +/- 6 months
Authors
Discussion
Loading...
Member takes
Implication
Transplant may not improve exercise capacity over medical therapy in HF survivors; leaves open whether LVEF gains translate to functional benefit.
Structured PICO
Does cardiac transplantation improve exercise capacity compared to sustained medical therapy in survivors with severe heart failure?
P
Population
42 survivors of severe heart failure (baseline LVEF 15 +/- 4%) who underwent exercise testing after more than 6 months of follow-up, out of an initial cohort of 146 referred patients.
I
Intervention
Cardiac transplantation
C
Comparator
Sustained medical therapy tailored to hemodynamic goals
O
Outcome
Exercise capacity (maximum workload, oxygen uptake, anaerobic threshold, or maximum oxygen pulse)surrogate
Survivors of severe heart failure managed with tailored medical therapy achieve similar exercise capacity to those who undergo cardiac transplantation, despite significantly lower ejection fractions.
Cite This Study
Stevenson et al. (1990) studied this question.