Key result
Dopexamine infusion at 1 micrograms/kg/min in post-MI heart failure patients decreased systemic vascular resistance index by 25% and increased cardiac index by 32% without developing tolerance over 24 hours.
Why the study?
Does dopexamine hydrochloride continuous infusion improve haemodynamic parameters in patients with heart failure after acute myocardial infarction?
Population
15 patients with heart failure after acute myocardial infarction
Design
Case_series
Follow-up
up to 24 hours
Authors
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May support short-term hemodynamic effects in post-MI HF; hypothesis-generating and leaves open need for RCTs before practice change.
Observational (n=15)
Does dopexamine hydrochloride continuous infusion improve haemodynamic parameters in patients with heart failure after acute myocardial infarction?
Dopexamine hydrochloride continuous infusion safely augments cardiac performance at rest in patients with post-infarction heart failure without developing tolerance over 24 hours.
Svenson et al. (1988) conducted an observational in Heart failure after acute myocardial infarction (n=15). Dopexamine hydrochloride was evaluated on Haemodynamic effects (systemic vascular resistance index, cardiac index, stroke volume index, heart rate). Dopexamine infusion at 1 micrograms/kg/min in post-MI heart failure patients decreased systemic vascular resistance index by 25% and increased cardiac index by 32% without developing tolerance over 24 hours.
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