Key result
IV dopexamine dose-dependently increases cardiac index and lowers systemic vascular resistance in chronic heart failure.
Why the study?
The acute haemodynamic and metabolic effects of dopexamine in patients with chronic heart failure were not well characterized.
Does intravenous dopexamine improve acute haemodynamic and metabolic parameters in patients with chronic heart failure?
Population
10 patients with chronic heart failure undergoing diagnostic cardiac catheterisation
Comparison
Dopexamine intravenous infusion in three incremental doses
Design
Case series
Follow-up
Acute during diagnostic cardiac catheterisation
Authors
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May improve acute hemodynamics in chronic heart failure; hypothesis-generating and should not yet change practice.
Does intravenous dopexamine improve acute haemodynamic and metabolic parameters in patients with chronic heart failure?
Intravenous dopexamine acutely improves hemodynamics and myocardial efficiency without significantly increasing myocardial oxygen consumption in patients with chronic heart failure.
Dawson et al. (1985) studied chronic heart failure (n=10). Dopexamine was evaluated on Acute haemodynamic and metabolic effects. Intravenous dopexamine produced significant dose-related increases in cardiac index and stroke volume index, and falls in systemic vascular resistance in patients with chronic heart failure.
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