Key result
Nitroglycerin with phenylephrine reduced ST-segment abnormalities in AMI patients without heart failure (4.9 to 3.2 mv, P<0.05), while nitroglycerin alone was effective in those with heart failure.
Why the study?
Does nitroglycerin alone or with phenylephrine reduce myocardial ischemic injury in patients with acute myocardial infarction?
Does nitroglycerin alone or with phenylephrine reduce myocardial ischemic injury in patients with acute myocardial infarction?
p-value: p=<0.05
Nitroglycerin reduces ischemic injury during AMI, but the optimal regimen (with or without phenylephrine) depends on the presence of baseline left ventricular failure.
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Suggests possible benefit of adding phenylephrine in non-HF AMI; hypothesis-generating case series requiring prospective confirmation.
Borer et al. (1975) studied Acute Myocardial Infarction (n=12). Nitroglycerin alone or with phenylephrine vs. Baseline was evaluated on Sum of ST-segment abnormalities (sigmaST) from 35 precordial electrodes (p=<0.05). Nitroglycerin with phenylephrine reduced ST-segment abnormalities in AMI patients without heart failure (4.9 to 3.2 mv, P<0.05), while nitroglycerin alone was effective in those with heart failure.
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