July 4, 2012Open Access
Risk factor reduction in progression of angiographic coronary artery disease.
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Key result
Patients with progressive coronary artery disease had significantly higher mean arterial blood pressure compared to those with nonprogressive disease (97 vs 92 mm Hg, p=0.01).
Why the study?
Are higher blood pressure and LDL-C levels associated with angiographic progression of coronary artery disease in outpatients?
Population
183 outpatients in a cardiology practice having ≥ 2 coronary angiographies ≥ 1 year apart, mean age 71 years.
Design
Cohort
Follow-up
mean 11 years (mean 58 months between angiographies)
Authors
Discussion
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Implication
Should not yet alter BP targets in CAD outpatients; hypothesis-generating for trials testing whether MAP reduction slows progression.
Study Design
Type
Observational (n=183)
Multicenter
No
Structured PICO
Are higher blood pressure and LDL-C levels associated with angiographic progression of coronary artery disease in outpatients?
P
Population
183 outpatients in a cardiology practice having ≥ 2 coronary angiographies ≥ 1 year apart, mean age 71 years.
O
Outcome
Progression of coronary artery disease (defined as new non-obstructive or obstructive CAD in a previously disease-free vessel; or new obstruction in a previously non-obstructive vessel) measured by coronary angiographysurrogate
Main Result
Absolute Event Rate: 97% vs 92%
p-value: p=0.01
Higher mean arterial blood pressure is significantly associated with angiographic progression of coronary artery disease in outpatients.
Limitations
- Retrospective study design
- Long time gap between the two coronary angiographies may have contributed to the progression of CAD
- Reasons for the first coronary angiography were not recorded in the outpatient charts for all patients
- Hemoglobin A1c levels were not measured in all diabetics
Cite This Study
Lai et al. (2012) conducted an observational in Coronary artery disease (n=183). Progressive coronary artery disease vs. Nonprogressive coronary artery disease was evaluated on Mean arterial blood pressure (mm Hg) (p=0.01). Patients with progressive coronary artery disease had significantly higher mean arterial blood pressure compared to those with nonprogressive disease (97 vs 92 mm Hg, p=0.01).
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