Key result
Over a median of 37.6 months, 38.8% of patients with initially normal or mild CAD developed some degree of CAD, with age, smoking, and hypertension identified as independent predictors.
Why the study?
CAD progresses slowly and patients with normal or near-normal coronary arteries remain at risk of developing CAD, with mild atherosclerosis believed to increase CAD rates.
Cohort (n=556)
No
Nearly 40% of patients with normal or mild CAD on initial angiography developed CAD progression over a median of 3 years, with age, smoking, hypertension, and angina presentation as independent predictors.
Warrants vigilance for progression in patients with hypertension or smoking; leaves open optimal surveillance and prevention strategies.
BACKGROUND: Coronary Artery Disease is one of the leading causes of death in the world. CAD usually progresses slowly during time and patients with normal or near-normal coronary arteries are also at risk of developing CAD. It is now believed that even mild atherosclerosis can increase the rate of CAD. METHODS: This is a retrospective, descriptive and analytic study. We selected patients who had undergone at least two diagnostic coronary angiographies at Tehran Heart Center and had normal coronary structure or mild CAD in initial angiography. The data was obtained from the Tehran Heart Center Angiography Databank. Predicting factors in the development of CAD were determined. RESULTS: Data on 556 patients were reviewed. The median interval between the initial and final coronary catheterization was 37.6 months. On the final evaluation, 216 patients (38.8%) found to have developed some degrees of coronary artery disease. Based on the multivariate analysis, age, hematocrit, cigarette smoking, hypertension, and initial presentation with stable and unstable angina were found to be independent predictors of progression to CAD in patients. CONCLUSION: In the end, 40% of patients who had normal coronary arteries or minimal CAD in the initial angiography report, developed some degrees of CAD and some clinical indices can predict the risk of CAD.
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Aghajani et al. (2021) conducted a cohort in Normal coronary angiograms or mild coronary artery disease (n=556). Risk factors (age, hematocrit, cigarette smoking, hypertension, angina presentation) vs. Absence of risk factors was evaluated on Development of some degrees of coronary artery disease. Over a median of 37.6 months, 38.8% of patients with initially normal or mild CAD developed some degree of CAD, with age, smoking, and hypertension identified as independent predictors.
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