Key result
In a pilot study of 76 patients, women reported higher prodromal symptom scores than men 4 to 6 months after an acute coronary syndrome event, particularly premenopausal and perimenopausal women.
Why the study?
Do prodromal symptoms of acute coronary syndrome differ by sex and menopausal status?
Observational (n=76)
Do prodromal symptoms of acute coronary syndrome differ by sex and menopausal status?
Women, particularly those who are premenopausal or perimenopausal, report a greater number and frequency of prodromal symptoms of ACS compared to men.
Should not yet change practice; hypothesis-generating for sex- and menopause-specific prodromal ACS symptoms.
Increasing evidence suggests that there are sex/gender differences in the presentation and prodromal symptoms of acute coronary syndrome (ACS). The purpose of this pilot study was to identify sex differences in the prodromal symptoms of ACS using the McSweeney Acute and Prodromal Myocardial Infarction Symptom Survey (MAPMISS). Telephone surveys using the MAPMISS were conducted between 4 and 6 months after the ACS event. Seventy-six patients (24 women) participated in the study. The women generally reported higher prodromal scores. Moreover, scores demonstrated differences in prodromal symptoms based on menopausal status. The premenopausal and perimenopausal women reported a greater number and higher frequency of symptoms compared with the men and menopausal women. The results of this study suggest that both men and women report nontraditional prodromal symptoms of ACS. In addition, there appears to be a difference in the frequency and number of symptoms reported based on menopausal status.
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Norris et al. (2008) conducted an observational in Acute coronary syndrome (n=76). Female sex vs. Male sex was evaluated on Prodromal symptoms of ACS using the MAPMISS. In a pilot study of 76 patients, women reported higher prodromal symptom scores than men 4 to 6 months after an acute coronary syndrome event, particularly premenopausal and perimenopausal women.
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