November 22, 2010Archives of Internal Medicine

Validation of an Atrial Fibrillation Risk Algorithm in Whites and African Americans

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Why the study?

Does a Framingham Heart Study-derived risk algorithm reliably predict incident atrial fibrillation in diverse cohorts of whites and African Americans?

Population

14,412 participants aged 45 to 95 years from three independent cohorts: Framingham Heart Study, Age…

Design

Cohort

Follow-up

5 years (100,074 person-years total)

Authors

RSRenate B. SchnabelBroad Institute TAThor AspelundPreventive Cardiology GLGuo LiTongji University

Discussion

Member takes

Implication

Supports recalibrated Framingham AF prediction in diverse cohorts; extends validation to African Americans but leaves open prospective testing.

Structured PICO

Does a Framingham Heart Study-derived risk algorithm reliably predict incident atrial fibrillation in diverse cohorts of whites and African Americans?

Population

14,412 participants aged 45 to 95 years from three independent cohorts: Framingham Heart Study (FHS, n=4,764), Age, Gene/Environment Susceptibility-Reykjavik Study (AGES, n=4,238), and Cardiovascular Health Study (CHS, n=5,410, of whom 874 [16.2%] were African Americans).

Intervention

Framingham Heart Study (FHS)-derived risk algorithm modified for 5-year incidence of atrial fibrillation (incorporating age, sex, body mass index, systolic blood pressure, electrocardiographic PR interval, hypertension treatment, and heart failure).

Outcome

5-year incidence of atrial fibrillationhard clinical

A Framingham-derived risk algorithm using routinely available clinical variables reliably predicts 5-year incident atrial fibrillation across diverse white and African American cohorts.

Cite This Study

Schnabel et al. (2010) studied this question.

synapsesocial.com/papers/6a0511c5fba2ba61ab55fbae https://doi.org/10.1001/archinternmed.2010.434

Topics

Heart failure HFrEF treatment Atrial fibrillation Persistent AF management Hypertension management

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Implication

Supports recalibrated Framingham AF prediction in diverse cohorts; extends validation to African Americans but leaves open prospective testing.

Validation of an Atrial Fibrillation Risk Algorithm in Whites and African Americans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Validation of an Atrial Fibrillation Risk Algorithm in Whites and African Americans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider