Key result
Left atrial roof thickness >3.1 mm predicts strong maintenance substrate and poor catheter ablation success.
Why the study?
Atrial remodeling plays a major role in AF progression, and left atrial wall thickness may serve as an indicator to investigate atrial remodeling substrate and predict response to catheter ablation.
Does left atrial wall thickness predict atrial remodeling substrate and response to catheter ablation in patients with persistent atrial fibrillation?
Observational (n=100)
Does left atrial wall thickness predict atrial remodeling substrate and response to catheter ablation in patients with persistent atrial fibrillation?
Left atrial wall thickness measured by cardiac CT is associated with the extent of atrial remodeling and may predict the success of catheter ablation in persistent atrial fibrillation.
Answers are grounded in this paper and cite their sources.
Left atrial roof thickness >3.10 mm was associated with strong substrate and lower ablation success in persistent AF; leaves open CT-guided risk stratification.
Atrial remodeling plays a significant role during the progression of atrial fibrillation (AF). Left atrial wall thickness (LAT) is a subjective and easily acquirable indicator referring to structural remodeling. Therefore, we aimed to investigate the association between LAT and atrial remodeling substrate, and to explore the predictive role of LAT about strong maintenance substrate and poor response to catheter ablation.LAT was measured by cardiac computed tomography in 2 selected locations (roof and floor) in 100 persistent AF patients. Then the low-dose-ibutilide-facilitated catheter ablation was performed and atrial maintenance substrate was categorized as weak, mild, and strong, based on the response to circumferential pulmonary vein isolation or complex fractionated atrial electrograms ablation. During follow-up, the success rate was evaluated. LAT showed a progressive thickening tendency from weak, mild, to strong maintenance substrate (roof: 2.2 mm vs. 2.6 mm vs. 3.9 mm, P < .0001; floor: 1.7 mm vs. 2.0 mm vs. 2.5 mm, P < .0001). During follow-up, the success rate of ablation was decreased with the maintenance substrate strengthening (weak 80%, mild 64.53%, strong 31.43%, P = .009). LA roof thickness >3.10 mm might be the predictor to strong atrial maintenance substrate and poor response to ablation.LAT was associated with the remodeling extent of atrial maintenance substrate and might predict the response to catheter ablation. These findings could help the clinicians to select the appropriate ablative strategy and predict the complexity and prognosis before catheter ablation.
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Zuo et al. (2019) conducted an observational in Persistent atrial fibrillation (n=100). Left atrial wall thickness (LAT) measurement was evaluated on Atrial maintenance substrate strength and success rate of ablation (p=<.0001). Left atrial roof thickness >3.10 mm predicted strong atrial maintenance substrate and poor response to catheter ablation (success rates: weak 80%, mild 64.5%, strong 31.4%; P=0.009).
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