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Systematic review on mechanisms driving alveolar-capillary barrier dysfunction in ARDS, suggesting new therapy directions.
The alveolar-capillary barrier (ACB) is essential to maintain the function of gas exchange. Acute respiratory distress syndrome (ARDS), is a critical disease characterized by complex etiology and significant clinical heterogeneity. ARDS is pathologically defined by the impairment of ACB integrity, fundamentally driven by maladaptive between alveolar epithelium and pulmonary endothelium that disrupt their coordinated barrier functions. This article systematically reviews the damage mechanism in ARDS, aiming to provide novel theoretical basis and research direction for clinical therapy optimization strategies and prognosis evaluation of ARDS.
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Shi et al. (2026) studied this question.
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