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May 14, 2026

The association between the planetary health diet index (PHDI) and muscular dystrophies: A mediating role of phenotypic age.

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Authors

XLXiaomei LinSHShaoqun HuangHGHongyang Gong

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Overview

Cross-sectional analysis reveals that dietary quality may influence muscular dystrophies via biological aging.

Key Points

  • This research aims to explore the relationship between the planetary health diet index (PHDI) and muscular dystrophies (MDs), focusing on the mediating role of phenotypic age.
  • Cross-sectional analysis of 2951 participants from the National Health and Nutrition Examination Survey (2011-2018)
  • Utilized multivariable logistic regression and mediation analysis
  • Investigated associations using restricted cubic splines.
  • Each 10-point increase in PHDI was associated with a 15% reduction in MDs prevalence (OR = 0.85, 95% CI: 0.73-0.99)
  • Each one-unit increase in phenotypic age was linked to a 7% increase in MDs prevalence (OR = 1.07, 95% CI: 1.01-1.14)
  • Mediation analysis indicated that phenotypic age accounted for part of the association between PHDI and MDs.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a05680ea550a87e60a20756https://doi.org/10.1097/md.0000000000048612
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Planetary Health Diet and Body Mass Distribution in Relation to Kidney Health: Evidence from NHANES 2003–20182025
  2. 2Associations of the planetary health diet index (PHDI) with asthma: the mediating role of body mass index2024 · 16 citations
  3. 3Planetary health diet index and risk of mortality and cardiovascular disease: evidence from the health and retirement study2026 · 2 citations
  4. 4Association of dietary index for gut microbiota with premature and all-cause mortality: A mediation analysis of biological age2026
  5. 5Planetary health diet adherence and risk of cognitive-behavioral disorders in children and adolescents: a retrospective cohort study.2026