Stereoselective Synthesis of 1'-α-Cyano Carbocyclic Pyrimidine Nucleoside Analogs via a Chelation-controlled 1'-α-Hydroxymethylation Strategy

Nicolas Biteau; Dharmeshkumar Patel; Ramyani De; Franck Amblard; Mahesh Kasthuri; Raymond Schinazi

doi:10.1039/d6ob00377j

January 1, 2026Organic & Biomolecular ChemistryOpen Access

Stereoselective Synthesis of 1'-α-Cyano Carbocyclic Pyrimidine Nucleoside Analogs via a Chelation-controlled 1'-α-Hydroxymethylation Strategy

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Key Points

This research aims to develop a novel synthetic route for 1'-α-cyano carbocyclic nucleoside analogs to act as antiviral agents.
Developed a stereoselective synthetic route for nucleoside analogs.
Utilized a chelation-controlled 1'-α-hydroxymethylation strategy.
Focused on producing 1'-α-cyano carbocyclic nucleoside derivatives.
Successfully synthesized 1'-α-cyano carbocyclic nucleoside analogs.
Demonstrated effective stereoselectivity in the synthesis process.
Showed promising structural motifs for potential antiviral applications.

Implication

Demonstrates the synthesis of 1'-α-cyano nucleoside analogs, suggesting their potential as antiviral agents.

Abstract

1’-α-Cyano nucleoside analogs have emerged as key structural motifs as antiviral agents. Due to their importance, we developed a novel stereoselective synthetic route to access 1’-α-cyano carbocyclic nucleoside analogs. The...

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Cite This Study

Biteau et al. (2026) studied this question.

synapsesocial.com/papers/6a056824a550a87e60a208e8 https://doi.org/10.1039/d6ob00377j

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Stereoselective Synthesis of 1'-α-Cyano Carbocyclic Pyrimidine Nucleoside Analogs via a Chelation-controlled 1'-α-Hydroxymethylation Strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

Stereoselective Synthesis of 1'-α-Cyano Carbocyclic Pyrimidine Nucleoside Analogs via a Chelation-controlled 1'-α-Hydroxymethylation Strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

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