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May 14, 2026

Impact of angiogenic factors and maternal endothelial dysfunction on pregnancy outcome.

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Authors

MPM PiklováNemocnice České BudějoviceAEA EschnerJKJ Klicnarová

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Implication

Randomized trial analyzes relationship between sFlt-1/PlGF ratio and preterm birth risk, suggesting its utility in pregnancy management.

Key Points

  • To evaluate the relationship between sFlt-1/PlGF ratio and adverse perinatal outcomes.
  • Included 78 patients admitted between 22+0 and 34+6 weeks of gestation.
  • Measured sFlt-1/PlGF ratios to assess their relationship to pregnancy outcomes.
  • Developed a model to estimate delivery probability within 3 or 7 days.
  • 47 patients delivered before 37 weeks of gestation, showing a significant correlation with sFlt-1/PlGF ratios.
  • Almost all women with an sFlt-1/PlGF ratio above 100 delivered before 37 weeks.
  • The model had high specificity (0.91) but low sensitivity (0.32 and 0.53) for predicting delivery timing.

Cite This Study

Piklová et al. (2026) studied this question.

synapsesocial.com/papers/6a05684ea550a87e60a20c16https://doi.org/10.48095/cccg202689
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