Key result
TAVR improves functional capacity, increasing 6-minute walk distance by ~40 m and boosting quality of life.
Why the study?
Does TAVR improve functional capacity and health-related quality of life in high surgical-risk patients with severe aortic stenosis?
Population
2,775 patients with severe aortic stenosis at high surgical risk, mean age 81.8 ± 2.1 years, 52% female…
Design
Meta-analysis
Follow-up
up to 12 months
Authors
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TAVR improves function and QoL in high-risk severe AS; reinforces evidence across RCTs and observational data up to 12 months.
Meta-Analysis (n=2,775)
Does TAVR improve functional capacity and health-related quality of life in high surgical-risk patients with severe aortic stenosis?
Effect estimate: MD >40 m (95% CI 9.69-73.28)
TAVR provides substantial improvements in functional capacity and health-related quality of life up to 12 months post-procedure in high-risk patients with severe aortic stenosis.
Straiton et al. (2017) conducted a meta-analysis in severe aortic stenosis (n=2,775). Transcatheter aortic valve replacement (TAVR) was evaluated on Functional capacity (6-minute walk test) (MD >40 m, 95% CI 9.69-73.28). Transcatheter aortic valve replacement significantly improved functional capacity, with a >40 m increase in the 6-minute walk test (95% CI 9.69-73.28), and health-related quality of life.
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