Key result
DAFI75 scale predicts atrial thrombosis in persistent nonvalvular AF with ~99% NPV.
Why the study?
Routine transesophageal echocardiography to detect left atrial appendage thrombus is limited by availability, cost, and complexity, making clinical predictors needed to guide in-depth instrumental examination in AF.
Can the DAFI75 scale predict left atrial appendage thrombosis in patients with persistent nonvalvular atrial fibrillation?
Cohort (n=551)
Randomly split into training and validation cohorts
Can the DAFI75 scale predict left atrial appendage thrombosis in patients with persistent nonvalvular atrial fibrillation?
Effect estimate: AUC 0.847 (95% CI 0.761-0.934)
The DAFI75 scale, incorporating clinical and echocardiographic parameters, can reliably predict the absence of left atrial appendage thrombosis in patients with persistent nonvalvular AF, potentially reducing the need for routine TEE before cardioversion.
No takes yet. Share an insight, caveat, or question.
DAFI75 may help rule out left atrial thrombus; leaves open whether it can safely reduce TEE use before cardioversion.
Мазур et al. (2023) conducted a cohort in Persistent nonvalvular atrial fibrillation (n=551). DAFI75 scale was evaluated on Left atrial appendage thrombosis (AUC 0.847, 95% CI 0.761-0.934). The DAFI75 scale predicted atrial thrombosis in patients with persistent nonvalvular atrial fibrillation with an AUC of 0.847 and a negative predictive value of 98.9% in the validation cohort.
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