Why the study?
Does dietary-induced weight loss improve myocardial deformation in people with overweight to obesity without established cardiovascular disease?
Does dietary-induced weight loss improve myocardial deformation in people with overweight to obesity without established cardiovascular disease?
Dietary-induced weight loss improves subclinical myocardial deformation parameters measured by CMR in individuals with overweight or obesity.
Supports weight loss for subclinical cardiac remodeling in obesity without CVD; hypothesis-generating and requires randomized confirmation.
). At baseline, the study cohort with overweight to obesity without established cardiovascular disease displayed significantly increased global circumferential strain (GCS), global radial strain (GRS) and LA size (all p < 0.0001 versus controls) but normal global longitudinal strain (GLS) and normal LA ejection fraction (all p > 0.05 versus controls). Dietary-induced weight loss led to a significant reduction in GCS, GRS and LA size irrespective of macronutrient composition (all p < 0.01). In a population with overweight to obesity without established cardiovascular disease subclinical myocardial changes can be detected applying CMR. After dietary-induced weight loss improvement of myocardial deformation could be shown. A potential clinical impact needs further studies.
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Bolz et al. (2024) studied this question.
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