Key result
~75% of INOCA patients have coronary vasomotion disorders linked to worse QoL than obstructive CAD.
Why the study?
To determine the prevalence and correlates of microvascular and vasospastic angina in patients with symptoms and signs of ischemia but no obstructive coronary artery disease.
What is the prevalence and correlates of microvascular and vasospastic angina in patients with INOCA?
Observational
What is the prevalence and correlates of microvascular and vasospastic angina in patients with INOCA?
Over 75% of INOCA patients have identifiable coronary vasomotion disorders, experiencing comparable angina burden but reduced quality of life compared to those with obstructive CAD.
May justify vasomotor testing in INOCA; leaves open whether targeted therapy improves quality of life.
BACKGROUND: Determine the prevalence and correlates of microvascular and vasospastic angina in patients with symptoms and signs of ischemia but no obstructive coronary artery disease (INOCA). METHODS: =0.041). RESULTS: =0.032]. CONCLUSIONS: Over three quarters of patients with INOCA have identifiable disorders of coronary vasomotion including microvascular and vasospastic angina. These patients have comparable angina burden but reduced quality of life compared to patients with obstructive coronary artery disease. Microvascular angina and vasospastic angina are distinct disorders that may coexist but differ in associated clinical characteristics, symptoms, and angina severity. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT03193294.
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Ford et al. (2019) conducted an observational in Ischemia and No Obstructive Coronary Artery Disease (INOCA). Over 75% of patients with INOCA have identifiable coronary vasomotion disorders, experiencing comparable angina burden but reduced quality of life compared to obstructive coronary artery disease.
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