Key result
Arterial vasodilators induce changes in cardiac anatomy compatible with cardiac volume overload being a major contributor to the lack of left ventricular mass regression despite blood pressure lowering.
Why the study?
Does cardiac volume load determine the response of cardiac mass to arterial vasodilator therapy in hypertension?
Population
Normotensive and hypertensive humans and rats
Design
Review
Authors
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Supports caution with arterial vasodilators for LV mass regression; leaves open optimal therapy selection in hypertensive LVH.
Does cardiac volume load determine the response of cardiac mass to arterial vasodilator therapy in hypertension?
Cardiac volume overload and sympathetic hyperactivity are major determinants of the lack of left ventricular mass regression observed with arterial vasodilator therapy.
Leenen et al. (1990) conducted a review in Hypertension. Arterial vasodilators was evaluated on Changes in cardiac anatomy / left ventricular mass. Arterial vasodilators induce changes in cardiac anatomy compatible with cardiac volume overload being a major contributor to the lack of left ventricular mass regression despite blood pressure lowering.
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