Key result
ACE inhibitors consistently regress LVH while arterial vasodilators may cause progression.
Why the study?
Different classes of antihypertensive drugs may have varying effects on left ventricular hypertrophy due to their distinct activation of cardiac trophic mechanisms despite all lowering blood pressure.
Do different classes of antihypertensive drugs reduce left ventricular hypertrophy in patients with hypertension?
Population
Patients with hypertension
Comparison
Different classes of antihypertensive drugs including ACE inhibitors and arterial vasodilators
Design
Review
Authors
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Supports considering ACE inhibitors for LVH regression; leaves open outcome trials by drug class.
Do different classes of antihypertensive drugs reduce left ventricular hypertrophy in patients with hypertension?
Different classes of antihypertensive drugs have varying effects on left ventricular hypertrophy regression, with ACE inhibitors consistently promoting regression while arterial vasodilators may not.
Leenen et al. (1991) conducted a review in Hypertension and left ventricular hypertrophy. Antihypertensive drugs (e.g., ACE inhibitors, arterial vasodilators) was evaluated on Regression of left ventricular hypertrophy (LVH). Different classes of antihypertensive drugs have varying effects on left ventricular hypertrophy, with ACE inhibitors consistently causing regression while arterial vasodilators may cause progression.
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