Key result
Antihypertensive drugs show differential activities on the prevention or regression of left ventricular hypertrophy, driven by blood pressure lowering and neuro-endocrine interactions.
Why the study?
Do various antihypertensive drugs prevent or regress left ventricular hypertrophy in animal models and human hypertensives?
Population
Animal models and human hypertensives
Design
Review
Authors
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Differential LVH effects may inform agent selection; leaves open optimal choices pending randomized confirmation.
Do various antihypertensive drugs prevent or regress left ventricular hypertrophy in animal models and human hypertensives?
The regression of left ventricular hypertrophy by antihypertensive therapy depends on both blood pressure reduction and the modulation of neuro-endocrine systems such as the RAAS and sympathetic nervous system.
Pieter A. van Zwieten (2000) conducted a review in Left ventricular hypertrophy (LVH) and hypertension. Antihypertensive drug treatment was evaluated. Antihypertensive drugs show differential activities on the prevention or regression of left ventricular hypertrophy, driven by blood pressure lowering and neuro-endocrine interactions.
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