March 27, 2000Archives of Internal Medicine
Regional and Racial Differences in Response to Antihypertensive Medication Use in a Randomized Controlled Trial of Men With Hypertension in the United States
Why the study?
Does residing in the Stroke Belt reduce the efficacy of antihypertensive medications in men with hypertension?
Population
1,105 men with hypertension from 15 US Veterans Affairs medical centers
Comparison
Antihypertensive medications in patients… vs Same antihypertensive medications in patients…
Design
RCT, randomized
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Stroke Belt residence warrants closer BP monitoring or alternative agents in hypertensive men; extends RCT evidence of regional disparities beyond race.
Structured PICO
Does residing in the Stroke Belt reduce the efficacy of antihypertensive medications in men with hypertension?
P
Population
1,105 men with hypertension from 15 US Veterans Affairs medical centers
I
Intervention
Antihypertensive medications (hydrochlorothiazide, atenolol, diltiazem, captopril, prazosin, or clonidine) in patients residing inside the Stroke Belt
C
Comparator
Same antihypertensive medications in patients residing outside the Stroke Belt
O
Outcome
Treatment success rates of diastolic blood pressure control at 1 yearsurrogate
Patients residing in the US Stroke Belt exhibit reduced blood pressure control in response to several common antihypertensive medications compared to those outside the region, even after adjusting for race and lifestyle factors.
Cite This Study
William C. Cushman (2000) studied this question.