February 1, 1995American Journal of Hypertension
Department of veterans affairs single-drug therapy of hypertension studyRevised figures and new data
Why the study?
Does single-drug antihypertensive therapy improve blood pressure control compared to placebo in men with untreated diastolic blood pressure of 95 to 109 mm Hg?
Population
1292 men with untreated diastolic blood pressure of 95 to 109 mm Hg
Comparison
Single-drug antihypertensive therapy with one of… vs Placebo
Design
RCT
Follow-up
1 year
Authors
Discussion
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Implication
Single-drug antihypertensives control BP in most men with stage 1-2 diastolic hypertension; extends evidence for agent-specific efficacy and age-race response differences.
Structured PICO
Does single-drug antihypertensive therapy improve blood pressure control compared to placebo in men with untreated diastolic blood pressure of 95 to 109 mm Hg?
P
Population
1292 men with untreated diastolic blood pressure of 95 to 109 mm Hg
I
Intervention
Single-drug antihypertensive therapy with one of six drugs (diltiazem, hydrochlorothiazide, prazosin, captopril, clonidine, or atenolol)
C
Comparator
Placebo
O
Outcome
Success, defined as achieving a diastolic blood pressure of < 90 mm Hg at the end of the drug titration period and maintaining a diastolic blood pressure of < 95 mm Hg for 1 year without drug intolerancesurrogate
Single-drug antihypertensive therapy is effective in a majority of stage 1 to 2 diastolic hypertensive men, with diltiazem showing the highest overall success rate and important age-by-race differences in response.
Cite This Study
Materson et al. (1995) studied this question.