Why the study?
Does sequential single-drug therapy improve blood pressure control in men with hypertension who failed initial monotherapy?
Population
352 men with hypertension who failed to achieve diastolic blood pressure goal after 8 to 12 weeks of initial…
Comparison
Random allocation to an alternate single… vs Other alternate single antihypertensive drugs.
Design
RCT, random allocation
Authors
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Supports sequential monotherapy before combinations after initial failure; extends RCT evidence for individualized agent selection in hypertension.
Does sequential single-drug therapy improve blood pressure control in men with hypertension who failed initial monotherapy?
Sequential single-drug therapy is an effective strategy for achieving blood pressure control in patients who fail initial antihypertensive monotherapy.
Barry J. Materson (1995) studied this question.
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