Key result
Spironolactone use in hospitalized patients was associated with adverse reactions in 20.8%, primarily hyperkalemia (8.6%), which reached 42.1% with concurrent potassium chloride and BUN ≥50 mg/100 ml.
Why the study?
What is the frequency and nature of adverse reactions to spironolactone in hospitalized medical patients?
Observational (n=788)
What is the frequency and nature of adverse reactions to spironolactone in hospitalized medical patients?
Spironolactone use in hospitalized patients is associated with a high rate of adverse reactions, particularly hyperkalemia, which is strongly exacerbated by renal impairment and concurrent potassium supplementation.
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Caution advised with spironolactone in hospitalized patients with renal impairment or potassium supplementation; leaves open need for updated safety data in contemporary cohorts.
D J Greenblatt (1973) conducted an observational in Hospitalized medical patients (n=788). Spironolactone was evaluated on Adverse reactions attributed to spironolactone. Spironolactone use in hospitalized patients was associated with adverse reactions in 20.8%, primarily hyperkalemia (8.6%), which reached 42.1% with concurrent potassium chloride and BUN ≥50 mg/100 ml.
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