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May 15, 2026

Outcomes of perforation after colorectal endoscopic submucosal dissection in a large prospective multicenter cohort.

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Authors

SBSimon BaillySLSarah LeblancMPMathieu Pioche

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Overview

Prospective cohort study explores perforation risks and outcomes in colorectal endoscopic submucosal dissection, indicating the need for careful monitoring.

Key Points

  • This study aims to investigate the clinical burden and risk factors of perforation during colorectal endoscopic submucosal dissection (ESD).
  • Analysis of 3770 colorectal ESD procedures performed at 13 centers in Belgium and France from September 2019 to September 2022.
  • Intraprocedural and delayed perforations were examined in a prospective cohort design.
  • Multivariable analysis was used to identify factors linked to intraprocedural perforation.
  • Intraprocedural perforation occurred in 314 cases (8.3%); delayed perforation occurred in 22 cases (0.6%), totaling 336 perforations (8.9%).
  • Conservative management was effective for 308 perforations (91.7%); 304/314 intraprocedural perforations were managed conservatively (96.8%).
  • Surgery was needed for 81.8% of delayed perforations (18/22); no deaths were directly linked to perforation.

Cite This Study

Bailly et al. (2026) studied this question.

synapsesocial.com/papers/6a06b998e7dec685947ac63dhttps://doi.org/10.1055/a-2814-4657
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of Risk Factors for Postoperative Delayed Perforation Following Endoscopic Submucosal Dissection of Gastrointestinal Stromal Tumors2026
  2. 2Risk factors for intraoperative and delayed perforation related with gastric endoscopic submucosal dissection2024 · 18 citations
  3. 3Conservative management of delayed perforation after colorectal endoscopic submucosal dissection: a single-center experience2026
  4. 4Analysis of Risk Factors for Postoperative Delayed Perforation Following Endoscopic Submucosal Dissection in the Treatment of Gastrointestinal Stromal Tumors2026
  5. 5Risk Factors of Adverse Outcomes for Colorectal ESD After Generalization of the Technique—A Multi-Centre Retrospective Study in Hong Kong2026 · 1 citations