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July 1, 2026BMC GastroenterologyOpen Access

Conservative management of delayed perforation after colorectal endoscopic submucosal dissection: a single-center experience

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Authors

JGJinhong GuanWLWenjie LiXGXiang Guo

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Overview

Retrospective analysis of conservative management outcomes for delayed perforation after colorectal ESD, highlighting clinical associations.

Key Points

  • This study aims to evaluate the clinical characteristics and outcomes of conservative management for delayed perforation after colorectal ESD.
  • Retrospective review of medical records of 21 patients with delayed perforation after colorectal ESD treated between May 2011 and May 2025.
  • Identification of two groups: Success Group (SG) and Failure Group (FG) based on management outcomes.
  • Comparative analysis of clinical, endoscopic, and laboratory findings between SG and FG.
  • SG had lower baseline serum creatinine (median 67.0 vs. 90.0 µmol/L, P = 0.023) and higher baseline albumin (mean 41.2 vs. 36.4 g/L, P = 0.042) compared to FG.
  • Higher rate of complete endoscopic closure in SG (P = 0.013).
  • During conservative management, SG exhibited a slower rise and more rapid decline in serum procalcitonin levels compared to FG.

Cite This Study

Guan et al. (2026) studied this question.

synapsesocial.com/papers/6a44afb45cd2549c8bc449echttps://doi.org/10.1186/s12876-026-05010-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes of perforation after colorectal endoscopic submucosal dissection in a large prospective multicenter cohort.2026 · 3 citations
  2. 2Analysis of Risk Factors for Postoperative Delayed Perforation Following Endoscopic Submucosal Dissection of Gastrointestinal Stromal Tumors2026
  3. 3Analysis of Risk Factors for Postoperative Delayed Perforation Following Endoscopic Submucosal Dissection in the Treatment of Gastrointestinal Stromal Tumors2026
  4. 4Safety of sedation-free endoscopic submucosal dissection of colon lesions: a single-center retrospective study2025
  5. 5Risk Factors of Adverse Outcomes for Colorectal ESD After Generalization of the Technique—A Multi-Centre Retrospective Study in Hong Kong2026 · 1 citations