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Analysis of Risk Factors for Postoperative Delayed Perforation Following Endoscopic Submucosal Dissection in the Treatment of Gastrointestinal Stromal Tumors

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Retrospective case-control study identifies risk factors for delayed perforation in GIST patients, suggesting the need for careful monitoring.

The study aims to identify independent risk factors for delayed perforation following endoscopic submucosal dissection in gastrointestinal stromal tumors.
Retrospective case-control study of 113 GIST patients post-ESD, comparing perforation group (n=13) and control group (n=100).
Risk factors analyzed using univariate and multivariate logistic regression.
Univariate analysis found tumor diameter >2.0 cm, severe submucosal fibrosis, and muscular layer injury as significant factors (all P < 0.05).
Multivariate analysis confirmed these factors as independent risk factors for delayed perforation (P < 0.05).
The perforation group had longer median hospital stays (16 vs 7.5 days) and delayed gastrointestinal recovery (all P < 0.05).

Lei et al. (2026) studied this question.

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Retrospective case-control study identifies risk factors for delayed perforation in GIST patients, suggesting the need for careful monitoring.