Key result
Insulin differentially altered transcapillary movement in isolated rat hearts, increasing subendothelial IGFBP-1 content up to 132% (p<0.05) while decreasing ECBP content to 62% (p<0.005).
Why the study?
Does insulin alter the transcapillary movement of IGF-binding proteins in isolated rat hearts?
Population
Isolated beating rat hearts
Comparison
Insulin perfusion at 1, 10, and 100 ng/ml vs Control hearts perfused in the absence of insulin
Design
Preclinical
Authors
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No immediate clinical implications from rat model; leaves open human relevance of insulin-regulated IGF transport.
Does insulin alter the transcapillary movement of IGF-binding proteins in isolated rat hearts?
Insulin differentially alters the transcapillary movement of specific IGF-binding proteins in the rat heart, suggesting a mechanism for nutrient-dependent transport of IGFs to peripheral tissues.
Bar et al. (1990) studied this question. Insulin vs. Absence of insulin (control) was evaluated on Transcapillary movement of IGFBP-1, IGFBP-2, and ECBP. Insulin differentially altered transcapillary movement in isolated rat hearts, increasing subendothelial IGFBP-1 content up to 132% (p<0.05) while decreasing ECBP content to 62% (p<0.005).
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