Why the study?
Does intensive BP treatment prevent ADHF in high cardiovascular risk hypertensive patients?
Does intensive BP treatment prevent ADHF in high cardiovascular risk hypertensive patients?
Intensive blood pressure reduction in high cardiovascular risk hypertensive patients is important for preventing acute decompensated heart failure events.
Answers are grounded in this paper and cite their sources.
May support intensive BP targets for ADHF prevention in high-risk hypertension; leaves open vascular mechanisms beyond LV remodeling.
=0.81). A separate analysis demonstrated that the reduction in ADHF events in the intensive treatment group in SPRINT was not due to the differential use of diuretics between the 2 treatment groups. Although intensive BP treatment resulted in a lower cardiovascular disease event rate, this was not significantly associated with changes in left ventricular mass, function, or fibrosis, as assessed in SPRINT HEART, an ancillary study to SPRINT. Intensive BP treatment, however, significantly attenuated increases in carotid-femoral pulse wave velocity. Overall, these data highlight the importance of preventing ADHF in high cardiovascular risk hypertensive patients by optimal BP reduction as tested in SPRINT.
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Raby et al. (2021) conducted a review in Hypertension. Intensive BP treatment was evaluated on ADHF events.
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