Why the study?
Variability in left atrial appendage anatomy requires tailored approaches to ensure safe deployment and complete closure without peridevice leaks in patients needing left atrial appendage occlusion.
Demonstrates the feasibility of using two simultaneous Amulet devices to achieve complete LAA occlusion in a patient with complex, large multilobar anatomy.
Supports dual Amulet feasibility for complex multilobar LAA; hypothesis-generating and should not yet change practice.
Left atrial appendage occlusion has become an important minimally invasive treatment option for patients with atrial fibrillation who previously interrupted or permanently discontinued oral anticoagulation due to bleeding risks or complications. The effectiveness of the therapy relies on the safety of device deployment and the complete closure of the left atrial appendage (LAA) with no peridevice leaks. The variability of the LAA anatomy seen on preprocedural imaging requires a tailored approach for successful exclusion. We hereby present a patient with a large multilobar LAA that required 2 simultaneous Amulet devices to achieve complete exclusion of the appendage.
No takes yet. Share an insight, caveat, or question.
Mohiuddin et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: