Key result
Combining ac-ATPase and fixed alk-ATPase staining methods in serial sections of rat skeletal muscle identified four distinct fiber clusters: Types I, IIA, IIBd, and IIBm.
Population
Normal Wistar rats (skeletal muscles: tibialis anterior, biceps brachii)
Design
Preclinical
Authors
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Should not alter clinical fiber typing; extends rodent histochemistry but leaves open human translation.
A two-dimensional quantitative histochemical approach combining different mATPase staining methods allows for the identification of four distinct skeletal muscle fiber types in rats, including two subgroups of Type IIB fibers.
Lind et al. (1991) studied Skeletal muscle fiber typing. ac-ATPase and fixed alk-ATPase staining was evaluated on Fiber type classification based on mATPase staining intensities. Combining ac-ATPase and fixed alk-ATPase staining methods in serial sections of rat skeletal muscle identified four distinct fiber clusters: Types I, IIA, IIBd, and IIBm.
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