Population
Human and rat muscle fibers
Comparison
Histochemical ATPase stains vs Quantitative enzyme assays of fragments of the…
Design
Preclinical
Key result
Quantitative enzyme assays showed essentially complete agreement with ATPase staining in distinguishing types I and II human muscle fibers, though agreement was less consistent for types IIA and IIB.
Authors
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Supports enzyme assays for type I/II fiber distinction in research; leaves open validation for IIA/IIB subtypes.
Histochemical ATPase staining and quantitative metabolic enzyme assays show complete agreement in distinguishing type I and II muscle fibers, but less consistency for subtypes.
Hintz et al. (1984) studied Muscle fiber typing. Quantitative enzyme assays vs. Myosin ATPase staining was evaluated on Agreement between ATPase staining and metabolic enzyme assays in distinguishing fiber types. Quantitative enzyme assays showed essentially complete agreement with ATPase staining in distinguishing types I and II human muscle fibers, though agreement was less consistent for types IIA and IIB.