Key result
ePWV shows weak association with measured cfPWV in older Black and White adults.
Why the study?
Few studies have directly compared estimated to measured carotid-femoral pulse wave velocity, particularly in non-White adults, and whether they correlate similarly with cardiovascular disease risk remains unexplored.
Does estimated carotid-femoral pulse wave velocity (ePWV) accurately reflect measured cfPWV and its associations with CVD risk factors in older Black and White adults?
Observational
Yes
Does estimated carotid-femoral pulse wave velocity (ePWV) accurately reflect measured cfPWV and its associations with CVD risk factors in older Black and White adults?
p-value: p=< 0.05
Estimated pulse wave velocity has only a weak agreement with measured carotid-femoral pulse wave velocity in older adults, suggesting it may not be a reliable substitute for direct measurement.
ePWV may not reliably substitute for cfPWV; leaves open its incremental prognostic value in older adults.
Introduction: Aortic stiffness offers important insight into vascular aging and cardiovascular disease (CVD) risk. The referent measure of aortic stiffness is carotid-femoral pulse wave velocity (cfPWV). cfPWV can be estimated (ePWV) from age and mean arterial pressure. Few studies have directly compared the association of ePWV to measured cfPWV, particularly in non-White adults. Moreover, whether ePWV and cfPWV correlate similarly with CVD risk remains unexplored. Aim: (1) To estimate the strength of the agreement between ePWV and cfPWV in both Black and White older adults; and (2) to compare the associations of ePWV and cfPWV with CVD risk factors and determine whether these associations were consistent across races. Methods and Results: < 0.05). cfPWV and ePWV were not associated with heart rate, triglycerides, and fasting glucose in Black adults, while both measures were negatively associated with BMI in Black adults. Conclusions: Findings suggest a weak association between ePWV and cfPWV in older White and Black adults from ARIC. There were similar weak associations between CVD risk factors with ePWV and cfPWV in White adults with subtle differences in associations in Black adults.
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Heffernan et al. (2022) conducted an observational in Aortic stiffness and cardiovascular disease risk. Estimated carotid-femoral pulse wave velocity (ePWV) vs. Measured carotid-femoral pulse wave velocity (cfPWV) was evaluated on Strength of agreement between ePWV and cfPWV and their associations with CVD risk factors (p=< 0.05). Estimated pulse wave velocity (ePWV) demonstrated a weak association with measured carotid-femoral pulse wave velocity (cfPWV) in older White and Black adults.