Key result
Reduced Holzapfel-Ogden law optimizes identifiability and fidelity for estimating passive cardiac mechanics via 3D MRI.
Population
In silico idealized left ventricle model and one in vivo healthy 28-year-old male volunteer with normal…
Comparison
Reduced form of the Holzapfel-Ogden constitutive… vs Other constitutive laws including Neo-Hookean…
Design
Preclinical
Authors
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Guides constitutive model selection in cardiac simulations; leaves open clinical translation pending human validation.
A reduced form of the Holzapfel-Ogden law optimally balances parameter identifiability and model fidelity for patient-specific cardiac mechanics modeling using 3D tagged MRI.
Hadjicharalambous et al. (2014) studied Healthy (cardiac mechanics modeling) (n=1). Reduced Holzapfel-Ogden constitutive law vs. Neo-Hookean, Neo-fiber, and Guccione laws was evaluated on Practical identifiability and model fidelity. A reduced form of the Holzapfel-Ogden law provided the best balance between practical identifiability and model fidelity for estimating passive cardiac mechanical parameters using 3D tagged MRI.
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