Key result
Coronary-artery bypass surgery showed no statistical difference in major cardiac events compared to medical therapy at 3 years, but reduced all unstable angina (6 vs 15 cases; P<0.01).
Why the study?
Does coronary-artery bypass surgery reduce major cardiac events and improve functional status in patients with stable, disabling angina compared to medical therapy?
Population
100 patients with stable, disabling angina
Comparison
Coronary-artery bypass surgery vs Medical therapy
Design
RCT, randomized
Follow-up
3 years
Authors
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CABG should not be pursued primarily to reduce major cardiac events in stable angina; confirms medical therapy equivalence for hard outcomes at 3 years.
RCT (n=100)
Does coronary-artery bypass surgery reduce major cardiac events and improve functional status in patients with stable, disabling angina compared to medical therapy?
Coronary artery bypass surgery improves functional status and reduces unstable angina compared to medical therapy in patients with stable angina, but does not significantly change the likelihood of death or myocardial infarction at three years.
Kloster et al. (1979) conducted an RCT in stable, disabling angina (n=100). coronary-artery bypass vs. medical therapy was evaluated on major cardiac events (death, infarction, and unstable angina requiring operation or reoperation). Coronary-artery bypass surgery showed no statistical difference in major cardiac events compared to medical therapy at 3 years, but reduced all unstable angina (6 vs 15 cases; P<0.01).
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