Population
Adult rat cardiac myocytes and S49 T-lymphoma cells
Comparison
Depolymerization of microtubules with colchicine… vs Untreated cells (implied)
Design
Preclinical
Authors
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Cytoskeletal disruption may boost beta-adrenergic cAMP in animal cardiomyocytes; leaves open relevance to human cardiac signaling or therapy.
Microtubules and actin filaments restrict cAMP formation by regulating the localization and interaction of GPCR-Gs-AC in lipid rafts/caveolae.
Head et al. (2006) studied this question.
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