April 18, 2006Journal of Biological ChemistryOpen Access

Focal Adhesions in (Myo)fibroblasts Scaffold Adenylyl Cyclase with Phosphorylated Caveolin

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Population

Adult rat cardiac fibroblasts

Comparison

Treatment with adenylyl cyclase activator… vs Control/untreated cells

Design

Preclinical

Authors

JSJames S. SwaneySpringhouse HPHemal H. PatelAmbulance Service of New South Wales UYUtako YokoyamaPediatric Cardiology

Discussion

Member takes

Implication

May guide antifibrotic research via caveolin-1; leaves open validation in cardiac disease models.

Structured PICO

Population

Adult rat cardiac fibroblasts

Intervention

Treatment with adenylyl cyclase activator forskolin or a cAMP analog, small interfering RNA knock-down of cav-1, and inhibition of protein tyrosine phosphatase 1B

Comparator

Control/untreated cells

Outcome

Distribution and expression of adenylyl cyclase, phospho-cav-1, and focal adhesion proteins, and actin cytoskeletal disruptionsurrogate

Phosphorylated caveolin-1 scaffolds adenylyl cyclase at focal adhesions, mediating cAMP-dependent inhibition of actin assembly and fibroblast-myofibroblast transformation.

Cite This Study

Swaney et al. (2006) studied this question.

synapsesocial.com/papers/6a6fa85935aa2c282ce0fe83 https://doi.org/10.1074/jbc.m513097200

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Focal Adhesions in (Myo)fibroblasts Scaffold Adenylyl Cyclase with Phosphorylated Caveolin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Focal Adhesions in (Myo)fibroblasts Scaffold Adenylyl Cyclase with Phosphorylated Caveolin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider