Key result
Three neutralizing monoclonal antibodies against human astrovirus reacted with capsid protein VP29 and prevented viral attachment to human Caco-2 intestinal cells.
Population
Human serotype 1 astrovirus and human Caco 2 intestinal cell monolayers
Design
Preclinical
Authors
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VP29-targeted antibodies merit preclinical exploration for astrovirus countermeasures; leaves open human efficacy, safety, and heterotypic protection.
The astrovirus capsid protein VP29 may be important in viral neutralization, heterotypic immunity, and virus attachment to target cells.
Bass et al. (1997) studied Astrovirus infection. Monoclonal antibodies against serotype 1 human astrovirus was evaluated on Neutralizing activity and epitope characterization. Three neutralizing monoclonal antibodies against human astrovirus reacted with capsid protein VP29 and prevented viral attachment to human Caco-2 intestinal cells.
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