Key result
Natural rotavirus infection in infants induced seroconversion more frequently to VP4 than to VP7, although VP7 seroconverters had higher titers.
Why the study?
What is the relative contribution of rotavirus surface proteins VP4 and VP7 to the induction of homotypic and heterotypic neutralizing antibodies in natural infections of young children?
Population
70 infants with serologically defined primary rotavirus infections
Design
Cohort
Authors
Loading...
Supports targeting both VP4 and VP7 for rotavirus vaccines; leaves open which drives superior protection in infants.
Observational (n=70)
What is the relative contribution of rotavirus surface proteins VP4 and VP7 to the induction of homotypic and heterotypic neutralizing antibodies in natural infections of young children?
In natural rotavirus infections, infants seroconvert more frequently to VP4 than VP7, but produce higher antibody titers to VP7, with both proteins inducing homotypic and heterotypic responses.
Menchaca et al. (1998) conducted an observational in Primary rotavirus infection (n=70). Natural rotavirus infection was evaluated on Neutralizing antibody (NtAb) titers and seroconversion to VP4 and VP7. Natural rotavirus infection in infants induced seroconversion more frequently to VP4 than to VP7, although VP7 seroconverters had higher titers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: