Why the study?
Does natural rotavirus infection elicit a major neutralization response directed against VP4 or VP7 in young children?
Does natural rotavirus infection elicit a major neutralization response directed against VP4 or VP7 in young children?
The major neutralization response in protective natural rotavirus infections of young children is directed against the VP4 protein rather than VP7, which has implications for vaccine development.
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Natural rotavirus immunity may favor VP4 over VP7; leaves open whether VP4-focused vaccines will enhance protection in trials.
Ward et al. (1993) studied this question.
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